Composition for cushions, wound dressings and other skin-contacting products
AssigneeCorium International, Inc.
InventorsValery G. Kulichikhin, Shoreh Parandoosh, Mikhail M. Feldstein, Sergey Antonov, Gary W. Cleary
Life of this patent
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Abstract
A skin-contacting adhesive composition is described which has improved initial tack, long-term adhesion, water uptake and translucency characteristics and may be prepared by melt extrusion. Uses of these compositions are also described, for example, their use in wound dressings.
Claims99
A skin-contacting adhesive composition comprised of a hydrophobic phase and a hydrophilic phase, wherein:
- (a) the hydrophobic phase comprises a hydrophobic polymer, at least one elastomeric plasticizer and a tackifying resin;
- and
- (b) the hydrophilic phase comprises:
- i) at least one material selected from the group consisting of low molecular weight cellulose derived polymers and naturally occurring polysaccharides;
- ii) at least one high molecular weight cellulose derived polymer;
- and
- iii) reinforcing clay particles.
A skin-contacting adhesive composition comprised of a hydrophobic phase and a hydrophilic phase, wherein:
- (a) the hydrophobic phase comprises:
- a hydrophobic polymer selected from the group consisting of butadiene acrylonitrile rubber, butyl rubbers, ethylene-propylene-diene terpolymers, isobutylene-isoprene copolymers, natural rubber adhesives, polychloroprenes, polyisobutylenes, polyisoprenes, polysiloxanes, styrene-butadiene-styrene block copolymers, styrene-isoprene-styrene block copolymers, vinyl ether polymers, and combinations thereof;
- at least one elastomeric plasticizer and a tackifying resin;
- and
- (b) the hydrophilic phase comprises:
- i) at least one material selected from the group consisting of low molecular weight cellulose derived polymers and naturally occurring polysaccharides;
- ii) at least one high molecular weight cellulose derived polymer;
- and
- iii) reinforcing clay particles.
An adhesive cushion for application to the skin, comprising:
- (a) a skin-contacting layer of an adhesive composition comprised of a hydrophobic phase and a hydrophilic phase, wherein:
- (i) the hydrophobic phase comprises a hydrophobic polymer, at least one elastomeric plasticizer and a tackifying resin;
- and
- (ii) the hydrophilic phase comprises:
- 1) at least one material selected from the group consisting of low molecular weight cellulose derived polymers and naturally occurring polysaccharides;
- 2) at least one high molecular weight cellulose derived polymer;
- and
- 3) reinforcing clay particles;
- and laminated thereto,
- (b) a backing layer.
A wound dressing comprising a laminated composite of a body facing layer having a body-contacting surface, and an outwardly facing non-occlusive backing layer, wherein at least a portion of the body-contacting surface is comprised of a skin-contacting adhesive comprised of a hydrophobic phase and a hydrophilic phase, wherein:
- (a) the hydrophobic phase comprises a hydrophobic polymer, at least one elastomeric plasticizer and a tackifying resin;
- and
- (b) the hydrophilic phase comprises:
- i) at least one material selected from the group consisting of low molecular weight cellulose derived polymers and naturally occurring polysaccharides;
- ii) at least one high molecular weight cellulose derived polymer;
- and
- iii) reinforcing clay particles.
A transdermal drug delivery device comprised of a drug reservoir containing a therapeutically effective amount of an active agent, an outwardly facing backing layer, and a means for affixing the device to a body surface comprising a skin-contacting adhesive composition, wherein the adhesive composition comprises:
- (a) a hydrophobic phase comprising a hydrophobic polymer, at least one elastomeric plasticizer and a tackifying resin;
- and
- (b) a hydrophilic phase comprising:
- i) at least one material selected from the group consisting of low molecular weight cellulose derived polymers and naturally occurring polysaccharides;
- ii) at least one high molecular weight cellulose derived polymer;
- and
- iii) reinforcing clay particles.
A skin-contacting adhesive composition comprised of a hydrophobic phase and a hydrophilic phase, wherein the hydrophilic phase comprises:
- i) randomly distributed spherical solid droplets comprised of a material selected from the group of low molecular weight cellulose derived polymers, naturally occurring polysaccharides, and combinations thereof;
- ii) fibers comprised of a liquid crystalline high molecular weight cellulose derived polymer;
- and
- iii) ordered particles comprised of clay.
Dependencies are inferred from the claim text.