Process of purification of paclitaxel and docetaxel

Abstract

A process for the purification of paclitaxel comprising: (a) mixing crude paclitaxel with a mixture of solvents such as alkane and chlorinated alkane, filtering the solid followed by drying to obtain paclitaxel of increased purity; (b) repeating step (a) one or more times to obtain paclitaxel of increased purity; (c) dissolving the solid obtained from step (b) in alkyl ketone followed by adding alkane thereto, filtering and drying the solid thus formed to obtain paclitaxel of increased purity; (d) repeating step (c) one or more times to increase the purity of paclitaxel; (e) dissolving the paclitaxel obtained from step (d) in alkanol and then adding water, filtering and drying the solid thus formed, to obtain paclitaxel of increased purity; and (f) dissolving the solid obtained from step (e) in alkyl ketone, filtering, followed by adding alkane to the filtrate, filtering and drying the solid thus formed to obtain pure paclitaxel.

Dependencies are inferred from the claim text.