Notch1 inhibitors for inducing apoptosis
OwnerSusan M. Freier, Kenneth W. Dobie +1inventors
InventorsSusan M. Freier, Kenneth W. Dobie, Erich Koller
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Abstract
Compounds, compositions and methods are provided for modulating the expression of Notch1. The compositions comprise oligonucleotides, targeted to nucleic acid encoding Notch1. Methods of using these compounds for modulation of Notch1 expression and for diagnosis and treatment of disease associated with expression Notch1 are provided.
Claims26
A compound 8 to 80 nucleobases in length targeted to a nucleic acid molecule encoding Notch1, wherein said compound specifically hybridizes with said nucleic acid molecule encoding Notch1 and inhibits the expression of Notch1.
A compound 8 to 80 nucleobases in length which specifically hybridizes with at least an 8-nucleobase portion of a preferred target region on a nucleic acid molecule encoding Notch1.
Dependencies are inferred from the claim text.