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US 2003/0225016 A1Published application
Chimeric immunomodulatory compounds and methods of using the same - III
AssigneeDynavax Technologies Corporation
InventorsKaren L. Fearon, Dino Dina, Stephen F. Tuck
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Abstract
The invention provides immunomodulatory compounds and methods for immunomodulation of individuals using the immunomodulatory compounds.
Claims33
A chimeric immunomodulatory compound (CIC) comprising two or more nucleic acid moieties and one or more non-nucleic acid spacer moieties,
- wherein each nucleic acid moiety is covalently joined to at least one non-nucleic acid spacer moiety,
- wherein at least one nucleic acid moiety comprises the sequence 5′-CG-3′, and
- wherein said CIC has immunomodulatory activity.
A multimeric CIC comprising a first CIC and a second CIC, wherein the first CIC is not a branched CIC, and wherein a nucleic acid moiety of the first CIC is at least partially complementary to a nucleic acid moiety of the second CIC, and the two nucleic acid moieties form a duplex structure.
Dependencies are inferred from the claim text.