Therapeutic polypeptides, nucleic acids encoding same, and methods of use

An isolated polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO:

• 2n, wherein n is an integer between 1 and 61.

An isolated polypeptide comprising an amino acid sequence which is at least 95% identical to an amino acid sequence selected from the group consisting of SEQ ID NO:

• 2n, wherein n is an integer between 1 and 61.

An isolated polypeptide, wherein the polypeptide comprises an amino acid sequence comprising one or more conservative substitutions in the amino acid sequence selected from the group consisting of SEQ ID NO:

• 2n, wherein n is an integer between 1 and 61.

A method of treating a pathological state in a mammal, the method comprising administering to the mammal a polypeptide in an amount that is sufficient to alleviate the pathological state, wherein the polypeptide is a polypeptide having an amino acid sequence at least 95% identical to a polypeptide comprising the amino acid sequence selected from the group consisting of SEQ ID NO:

• 2n, wherein n is an integer between 1 and 61 or a biologically active fragment thereof.

An isolated nucleic acid molecule comprising a nucleic acid sequence selected from the group consisting of SEQ ID NO:

• 2n−1, wherein n is an integer between 1 and 61.

A nucleic acid molecule, wherein the nucleic acid molecule differs by a single nucleotide from a nucleic acid sequence selected from the group consisting of SEQ ID NO:

• 2n−1, wherein n is an integer between 1 and 61.

An isolated nucleic acid molecule encoding the mature form of a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:

• 2n, wherein n is an integer between 1 and 61.

An isolated nucleic acid molecule comprising a nucleic acid selected from the group consisting of 2n−1, wherein n is an integer between 1 and 61.