Glycopeptide antibacterial compounds, compositions containing same and methods of using same
AssigneePrinceton University
InventorsRonald M. Kim, Daniel E. Kahne, Kevin T. Chapman
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Abstract
The present invention relates to vancomycin analogs in which the vancosamine residue is substituted with a lipid-like substituent that includes a first aryl moiety and a second aryl moiety joined together by a flexible linker moiety, that is not a single bond directly joining the first aryl moiety and the second aryl moiety, and a glucose C-6 substituent modified to be other than the naturally occurring hydroxyl group, or pharmaceutically acceptable salts thereof.
Claims47
A vancomycin analog whose glucose C-6 position is modified to bear a polar substituent other than a naturally occurring hydroxyl group and whose vancosamine is substituted at the amine nitrogen with a lipid-like substituent having at least a first aryl moiety and second aryl moiety joined together by a first flexible linker moiety that it is not a single bond, directly joining the first aryl moiety and the second aryl moiety or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.