Measuring chip for surface plasmon resonance biosensor and method for producing the same
AssigneesDai Nippon Printing Co., Ltd., Isao Karube
InventorsRuna Nakamura, Hiroyuki Nakamura, Ryohei Nagata, Isao Karube, Hitoshi Muguruma
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Abstract
An objective of the present invention is to provide a measuring chip for a surface plasmon resonance sensor that can detect a small amount of target substances in high sensitivity. The present invention provides a measuring chip for a surface plasmon resonance sensor comprising a metal layer, one or more plasma polymerization layers formed on said metal layer, and a biologically active substance immobilized on the surface of said plasma polymerization layer.
Claims63
A measuring chip for a surface plasmon resonance sensor comprising a metal layer and one or more plasma polymerization layers formed on said metal layer.
A measuring chip for a surface plasmon resonance sensor comprising a metal layer, one or more plasma polymerization layers formed on said metal layer, and a nucleic acid immobilized on the surface of said plasma polymerization layer.
A measuring chip for a surface plasmon resonance sensor comprising a metal layer, one or more plasma polymerization layers formed on said metal layer, and a non-immune protein immobilized on the surface of said plasma polymerization layer.
A measuring chip for a surface plasmon resonance sensor comprising a metal layer, one or more plasma polymerization layers formed on said metal layer, and an immunoglobulin-binding protein immobilized on the surface of said plasma polymerization layer.
A measuring chip for a surface plasmon resonance sensor comprising a metal layer, one or more plasma polymerization layers formed on said metal layer, and a sugar-binding protein immobilized on the surface of said plasma polymerization layer.
A measuring chip for a surface plasmon resonance sensor comprising a metal layer, one or more plasma polymerization layers formed on said metal layer, and a sugar-recognizing sugar chain immobilized on the surface of said plasma polymerization layer.
A measuring chip for a surface plasmon resonance sensor comprising a metal layer, one or more plasma polymerization layers formed on said metal layer, and a fatty acid or a fatty acid ester immobilized on the surface of said plasma polymerization layer.
A measuring chip for a surface plasmon resonance sensor comprising a metal layer, one or more plasma polymerization layers formed on said metal layer, and a polypeptide or oligopeptide having ligand-binding activity immobilized on the surface of said plasma polymerization layer.
A measuring chip for a surface plasmon resonance sensor comprising a metal layer, one or more plasma polymerization layers formed on said metal layer, and an immune protein or enzyme immobilized on the surface of said plasma polymerization layer, wherein said plasma polymerization layer comprises a monomer material selected from the group consisting of pyridine, triethylamine, diethylamine, allylamine, acrylamide, aniline, acrylonitrile, 1,2,4-triazole, 5-amino-1H-tetrazole, and acetonitrile.
A measuring chip for a surface plasmon resonance sensor comprising a metal layer, a plasma polymerization layer formed on said metal layer, a substance immobilized on the surface of said plasma polymerization layer, and an additional plasma polymerization layer or plasma-treated layer formed on said plasma polymerization layer.
A measuring chip for a surface plasmon resonance sensor, comprising a metal layer, one or more plasma polymerization layers formed on said metal layer, and a substance immobilized on said plasma polymerization layer through a hydrophobic bond.
A method for producing a measuring chip for a surface plasmon resonance sensor comprising the steps of forming a metal layer on an optically transparent substrate, forming one or more plasma polymerization layers on said metal layer, and then immobilizing a nucleic acid on the surface of said plasma polymerization layer.
A method for producing a measuring chip for a surface plasmon resonance sensor comprising the steps of forming a metal layer on an optically transparent substrate, forming one or more plasma polymerization layers on said metal layer, and then immobilizing a non-immune protein on the surface of said plasma polymerization layer.
A method for producing a measuring chip for a surface plasmon resonance sensor comprising the steps of forming a metal layer on an optically transparent substrate, forming one or more plasma polymerization layers on said metal layer, and then immobilizing an immunoglobulin-binding protein on the surface of said plasma polymerization layer.
A method for producing a measuring chip for a surface plasmon resonance sensor comprising the steps of forming a metal layer on an optically transparent substrate, forming one or more plasma polymerization layers on said metal layer, and then immobilizing a sugar-binding protein on the surface of said plasma polymerization layer.
A method for producing a measuring chip for a surface plasmon resonance sensor comprising the steps of forming a metal layer on an optically transparent substrate, forming one or more plasma polymerization layers on said metal layer, and then immobilizing a sugar-recognizing sugar chain on the surface of said plasma polymerization layer.
A method for producing a measuring chip for a surface plasmon resonance sensor comprising the steps of forming a metal layer on an optically transparent substrate, forming one or more plasma polymerization layers on said metal layer, and then immobilizing a fatty acid or fatty acid ester on the surface of said plasma polymerization layer.
A method for producing a measuring chip for a surface plasmon resonance sensor comprising the steps of forming a metal layer on an optically transparent substrate, forming one or more plasma polymerization layers on said metal layer, and then immobilizing a polypeptide or oligopeptide having a ligand binding capability on the surface of said plasma polymerization layer.
Dependencies are inferred from the claim text.