DNA sequence encoding a human imidazoline receptor and method for cloning the same
AssigneeUniversity of Mississippi Medical Center
InventorsJohn E. Piletz, Tina R. Ivanov
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Abstract
A cDNA encoding a human imidazoline receptor is described. The amino acid sequence of the entire imidazoline receptor protein is identified, as well as a C-terminal fragment believed to contain the imidazoline binding site of the receptor. The protein is highly unique in its sequence and may represent the first in a novel family of receptor proteins. Methods of cloning the cDNA and expressing the imidazoline receptor in a host cell are described. Also, a screening method for identifying drugs that interact with the imidazoline receptor is described.
Claims25
An isolated polypeptide comprising the amino acid sequence shown in SEQ ID No. 6.
An isolated polypeptide comprising the amino acid sequence shown in SEQ ID No. 7.
A vector containing a nucleotide sequence as shown in SEQ ID No. 2, 3, 4, or 5.
Dependencies are inferred from the claim text.