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US 2003/0224427 A1Published application
Human receptor proteins; related reagents and methods
AssigneeSchering Corporation, a New Jersey corporation
InventorsChristi L. Parham, Kevin W. Moore, Nicholas J. Murgolo, J. Fernando Bazan
Life of this patent
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Abstract
Nucleic acids encoding mammalian, e.g., primate or rodent receptors, purified receptor proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are provided.
Claims20
A composition of matter selected from:
- a) a substantially pure or recombinant DIRS1 polypeptide comprising at least three distinct nonoverlapping segments of at least four amino acids identical to segments of SEQ ID NO:
- 2;
- b) a substantially pure or recombinant DIRS1 polypeptide comprising at least two distinct nonoverlapping segments of at least five amino acids identical to segments of SEQ ID NO:
- 2;
- c) a natural sequence DIRS1 comprising mature SEQ ID NO:
- 2;
- d) a fusion polypeptide comprising DIRS1 sequence;
- e) a substantially pure or recombinant DIRS2 polypeptide comprising at least three distinct nonoverlapping segments of at least ten amino acids identical to segments of SEQ ID NO:
- 4;
- f) a substantially pure or recombinant DIRS2 polypeptide comprising at least two distinct nonoverlapping segments of at least eleven amino acids identical to segments of SEQ ID NO:
- 4;
- g) a natural sequence DIRS2 comprising SEQ ID NO:
- 4;
- or h) a fusion polypeptide comprising DIRS2 sequence.
11 more elements
A nucleic acid which:
- a) hybridizes under wash conditions of 30 minutes at 30° C. and less than 2M salt to the coding portion of SEQ ID NO:
- 1;
- b) hybridizes under wash conditions of 30 minutes at 30° C. and less than 2M salt to the coding portion of SEQ ID NO:
- 3;
- c) exhibits identity over a stretch of at least about 30 nucleotides to a primate DIRS1;
- or
- d) exhibits identity over a stretch of at least about 30 nucleotides to a primate DIRS2.
4 more elements
A method of modulating physiology or development of a cell or tissue culture cells comprising contacting said cell with an agonist or antagonist of a mammalian DIRS1 or DIRS2.
Dependencies are inferred from the claim text.