Schizophrenia related gene
OwnerSusan Cochran, Keiji Yamagami +1inventors
InventorsSusan Cochran, Keiji Yamagami, Yoshitaka Ohashi
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Abstract
The present invention provides a new use of the polynucleotide of SEQ ID NO:1, NO:3 and NO:5 or fragments thereof, or the polypeptide encoded from that polynucleotide in the field of the schizophrenia.
Claims16
A method for diagnosing schizophrenia, which comprises use of at least one kind of polynucleotide selected from the group consisting of a polynucleotide having SEQ ID NO:1, a polynucleotide having SEQ ID NO:3, a polynucleotide having SEQ ID NO:5, a fragment thereof, and a polynucleotide having a sequence complementary to such sequence, as an index of schizophrenia.
A method for diagnosing schizophrenia, which comprises use of at least one kind of polypeptide selected from the group consisting of a polypeptide encoded by the polynucleotide of SEQ ID NO:1, a polypeptide encoded by the polynucleotide of SEQ ID NO:3, a polypeptide encoded by the polynucleotide of SEQ ID NO:5, and a fragment thereof, as an index of schizophrenia.
A method for identifying a compound modulating the activity of Kv3 channels, which comprises analyzing an expression of Kv3 channel using at least one kind of polynucleotide selected from the group consisting of a polynucleotide having SEQ ID NO:1, a polynucleotide having SEQ ID NO:3, a polynucleotide having SEQ ID NO:5, a fragment thereof and a polynucleotide having a sequence complementary to such sequence.
A method for identifying a compound modulating the activity of Kv3 channels, which comprises analyzing an expression of Kv3 channel using at least one kind of polypeptide selected from the group consisting of a polypeptide encoded by the polynucleotide of SEQ ID NO:1, a polypeptide encoded by the polynucleotide of SEQ ID NO:3, a polypeptide encoded by the polynucleotide of SEQ ID NO:5, and a fragment thereof.
11 The method of claim 10, wherein the expression of Kv3 channels is analyzed using at least one kind of polypeptide selected from the group consisting of a polypeptide encoded by the polynucleotide of SEQ ID NO:1, a polypeptide encoded by the polynucleotide of SEQ ID NO:3, and a polypeptide encoded by the polynucleotide of SEQ ID NO:5.
A method for screening a compound regulating the expression of at least one kind of polynucleotide selected from the group consisting of a polynucleotide having SEQ ID NO:1, a polynucleotide having SEQ ID NO:3 and a polynucleotide having SEQ ID NO:5, which comprises the steps of
- (a) bringing a test compound into contact with a cell (as used herein, the cell is capable of expression of polynucleotide, which is at least one kind of polynucleotide selected from the group consisting of a polynucleotide having SEQ ID NO:1, a polynucleotide having SEQ ID NO:3, a polynucleotide having SEQ ID NO:5 and a fragment thereof, and whose expression is desired to be controlled;
- (b) detecting the expression of polypeptide encoded by the polynucleotide in the cell;
- and
- (c) determining a compound promoting or suppressing the expression of the polypeptide as compared to a control (administration of vehicle alone).
A method for screening a compound regulating the expression of a polynucleotide having SEQ ID NO:1, which comprises the steps of:
- (a) bringing a test compound into contact with a cell (as used herein, the cell is capable of expression of a polynucleotide having SEQ ID NO:1);
- (b) detecting the expression of polypeptide encoded by the polynucleotide in the cell;
- and
- (c) determining a compound promoting or suppressing the expression of the polypeptide as compared to a control (administration of vehicle alone).
A method for screening a compound regulating the expression of at least one kind of polynucleotide selected from the group consisting of a polynucleotide having SEQ ID NO:1, a polynucleotide having SEQ ID NO:3 and a polynucleotide having SEQ ID NO:5, which comprises the steps of:
- (a) bringing a test compound into contact with a cell (as used herein, the cell is capable of expression of polynucleotide, which is at least one kind of polynucleotide selected from the group consisting of a polynucleotide having SEQ ID NO:1, a polynucleotide having SEQ ID NO:3, and a polynucleotide having SEQ ID NO:5, and whose expression is desired to be controlled);
- (b) detecting the expression of polynucleotide in the cell;
- and
- (c) determining a compound promoting or suppressing the expression of the polynucleotide as compared to a control (administration of vehicle alone).
A method for screening a compound regulating the expression of a polynucleotide having SEQ ID NO:1, which comprises the steps of:
- (a) bringing a test compound into contact with a cell (as used herein, the cell is capable of expression of polynucleotide having SEQ ID NO:1);
- (b) detecting the expression of polynucleotide in the cell;
- and
- (c) determining a compound promoting or suppressing the expression of the polynucleotide as compared to a control (administration of vehicle alone).
Dependencies are inferred from the claim text.