Diagnosis of a person's risk of developing alcoholism
OwnerJussi Kauhanen, Matti Karvonen +3inventors
InventorsJussi Kauhanen, Matti Karvonen, Ullamari Pesonen, Markku Koulu, Matti Uusitupa
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Abstract
The invention relates to methods for diagnosing a person's susceptibility for having a risk for the development of alcoholism. The invention relates further to methods for treating persons diagnosed for having risk for the development of alcoholism in order to prevent the development of said condition. The invention also concerns methods to investigate or screen pharmaceuticals or genetic aims useful in the treatment of said condition, by using an animal model including a transgenic animal.
Claims9
A method for diagnosing a person's susceptibility for having a risk for the development of alcoholism, said method comprising determining whether said subject has a polymorphism in the signal peptide part of the human preproNPY, said polymorphism comprising the subsitution of the position 7 leucine for proline in the signal peptide part of said preproNPY, said polymorphism being indicative of a risk for the development of alcoholism.
A method to investigate or screen pharmaceuticals or genetic aims useful in the prevention or treatment of alcoholism, by using an animal model including a transgenic animal which carries a human DNA sequence comprising a nucleotide sequence encoding a prepro-neuropeptide Y (preproNPY) or part thereof encoding mature human NPY peptide, where the leucine amino acid in position 7 of the signal peptide part of said preproNPY i) is unchanged or ii) has been replaced by proline.
A method to investigate or screen pharmaceuticals or genetic aims useful in the prevention or treatment of alcoholism, by using an animal model including a transgenic animal, which carries a DNA sequence comprising a nucleotide sequence encoding otherwise normal mouse NPY sequence or part thereof encoding mature mouse NPY peptide, but in which the nucleotide sequence encoding the mouse signal peptide is replaced by human signal peptide sequence encoding either normal or mutated human signal peptide.
Dependencies are inferred from the claim text.