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AssigneeArch Development Corporation
InventorsGraeme I. Bell, Kazuya Yamagata, Naohisha Oda, Pamela J. Kaisaki, Hiroto Furuta, Yukio Horikawa, Stephan Menzel
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The present invention relates generally to the fields diabetes. More particularly, it concerns the identification of genes responsible for NIDDM for use in diagnostics and therapeutics. The present invention demonstrates that the MODY3 locus is, in fact, the HNF1α gene, MODY4 locus is the HNF1β and the MODY1 locus is the HNF4α gene. The invention further relates to the discovery that analysis of mutations in the HNF1α, HNF1β and HNF4α genes can be diagnostic for diabetes. The invention also contemplates methods of treating diabetes in view of the fact that HNF1α, HNF1β and HNF4α mutations can cause diabetes.
A method for screening for diabetes comprising:
A method of regulating diabetes in an animal comprising the step of modulating HNF function in the animal.
A method of screening for modulators of HNF function comprising the steps of:
A method of screening for modulators of HNF function comprising the steps of:
An HNF modulator prepared by a process comprising screening for modulators of HNF function comprising:
An HNF modulator prepared by a process comprising screening for modulators of HNF function comprising:
An isolated and purified polynucleotide having an HNF1α-encoding nucleic acid sequence.
An isolated and purified polynucleotide having an HNF1β-encoding nucleic acid sequence.
An isolated and purified nucleic acid segment comprising 15 contiguous nucleic acids identical to the sequence of SEQ ID NO:128 or SEQ ID NO:
Dependencies are inferred from the claim text.