Methods of screening for SCAP antagonists
OwnerThierry Andre Regis Grand-Perret, Marc Issandouinventors
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Abstract
The invention relates to a method for screening therapeutic agents, defined as SCAP antagonists, for use in combating diseases associated with elevated lipid levels, said method comprising detecting or assaying the extent or result of transcriptional activity or binding between a control SCAP antagonist and SCAP, in the presence of and absence of said agent. Also claimed are therapeuic agents which are antagonists of SCAP, identified by such a method and their use in combating diseases associated with elevated lipid levels.
Claims10
A method for screening agents which bind to SCAP in a way which has the opposite effect to cholesterol and its metabolites by promoting the activation of the SCAP/SREBP pathway (SCAP antagonists), for use in combating diseases associated with elevated circulating levels of LDL-cholesterol and/or triglycerides, said method comprising detecting or assaying the extent or result of transcriptional activity or binding competition on SCAP between a test SCAP antagonist and a control SCAP antagonist, or between a test SCAP antagonist and cholesterol, or a metabolite thereof.
A method for the treatment of a mammal, including man, of conditions resulting from elevated circulating levels of LDL-cholesterol and/or triglycerides, comprising administration of an effective amount of a SCAP antagonist, or a physiologically acceptable salt, solvate or derivative thereof.
A method for identifying compounds which will be useful in for the treatment of conditions resulting from elevated circulating levels of LDL-cholesterol and/or triglycerides comprising the step of determining whether the compound interacts directly with SCAP.
Dependencies are inferred from the claim text.