Drug dose-form and method of manufacture
OwnerMichael K. Weibelinventor
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Abstract
Disclosed is a novel solid dosage unit, preferably in the form of a film or thin troche, containing at least one pharmaceutical agent, and its method of manufacture, which involves introduction of a fluid containing at least one non-volatile material, such as a polymeric film forming substance, a volatile carrier and at least one pharmaceutical agent into a depression or cavity comprising the major element of the packaging film for the finished dosage unit (s), and removing the volatile carrier from the cavity by exposure to radiant energy, whereby the remaining non-volatile residue comprises the desired dosage unit. The packaging film can be subsequently lidded by conventional sealing methods to produce packaged dosage units which are suitable for sublingual and other oral applications.
Claims25
A method for producing a dosage unit of at least one systemically active pharmaceutical agent as an orally administrable, solid, said method comprising:
- a. providing a sheet material having at least one depression therein;
- b. providing a flowable composition comprising said at least one pharmaceutical agent, a pharmaceutically acceptable non-volatile material and a volatile carrier medium;
- c. depositing said composition in said at least one depression;
- and
- d. subjecting said deposited composition to radiant energy which is effective to volatilize said carrier medium, thereby yielding said solid dosage unit comprising said non-volatile material and said at least one pharmaceutical agent.
Dependencies are inferred from the claim text.