Antimicrobial coatings
AssigneeUnisearch Limited
InventorsRoger W Read, Naresh Kumar, Mark Wilcox, Hua Zhu, Hans Griesser, Ben Muir, Helmut Thissen, Tim Hughes
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Abstract
The present invention provides a substrate having a plurality of immobilised furanone moieties associated with at least part of a surface of the substrate. The invention also relates to articles consisting of or comprising such a substrate.
Claims30
A substrate having a plurality of immobilised furanone moieties associated with at least part of a surface of the substrate, wherein the furanone moieties are derived from at least one compound selected from a furanone compound or an analog thereof.
A substrate according to any one of the previous claims wherein the furanone compound is of the formula:
- 7
- wherein R1 is a moiety selected from the group consisting of H, halogen, formyl, carboxyl, cyano, ester, amide, alkyl, alkoxy, oxoalkyl, alkenyl, alkynyl, aryl or arylalkyl, which moiety may optionally be
- substituted by one or more substituents;
- and/or
- interrupted by one or more hetero atoms;
- and/or
- straight chain, branched chain, hydrophobic, hydrophilic and/or fluorophilic;
- R2, R3 and R4 are independently or all H or halogen;
- and “═” represents either a double bond or a single bond.
A substrate according to any one of the preceding claims, wherein immobilisation on the surface is by means of covalent bonding.
A substrate according to any one of the previous claims, wherein the surface of the substrate has been subjected to surface activation prior to immobilisation of the furanone moieties.
A substrate according to any one of the preceding claims wherein one or more interfacial bonding layers are provided on the surface of the substrate to which are bonded the furanone moieties, the interfacial layer(s) optionally subjected to surface activation prior to immobilisation of the furanone moieties.
A substrate according to any one of the preceding claims wherein the material of the substrate is selected from at least one of the group consisting of metals, ceramics, glasses, natural polymers, synthetic polymers and natural materials.
A substrate according to any one of the preceding claims, wherein the substrate is solid, semi-solid, rigid or flexible.
A substrate according to any one of the preceding claims, which is shaped.
A substrate according to any one of the preceding claims in the form of a natural or synthetic filament or fibre.
A substrate according to any one of the preceding claims in the form of a woven or non-woven film, sheet or textile.
A substrate according any one of the preceding claims, which is formed from a material that is suitable for use in a biomedical application.
An article consisting of or comprising a substrate in accordance with any one of the preceding claims.
A method of forming an antimicrobial and/or antifungal layer on a substrate including:
- (a) providing a substrate;
- (b) providing at least one furanone compound or an analog thereof;
- (c) optionally treating at least part of the surface of the substrate to activate the surface;
- (d) reacting the at least one furanone compound or an analog thereof with the optionally treated surface to immobilize the at least one furanone or analog thereof.
Dependencies are inferred from the claim text.