Proteases from carica having mitogenic activity and their methods of use
OwnerCarlos E. Salas, MARIAM T. P. Lopes +1inventors
InventorsCarlos E. Salas, MARIAM T. P. Lopes, Abraham V. Schnidermann
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Abstract
Proteases having mitogenic activity isolated from the genus Carica are provided. In particular the proteases are cysteine proteases isolated from Carica candamarcensis. In addition, the recombinant forms of the protease, including fragments and mutants with substantial homology are provided. Also provided are pharmaceutical compositions useful for treating wounds that include the disclosed proteases with mitogenic activity. A method of treating wounds is provided using the disclosed proteases.
Claims17
A wound treating composition comprising an amount of a protease effective to treat a wound, wherein the protease stimulates cell proliferation and is selected from the group consisting of a natural protease isolated from genus Carica, a recombinant protease identical to the natural protease, and conservative mutations thereof.
A method of treating wounds comprising administering to a wound an amount of a protease effective to treat a wound, wherein the protease stimulates cell proliferation and is selected from the group consisting of a natural protease isolated from genus Carica, a recombinant protease identical to the natural protease, and conservative mutations thereof.
A protease isolated from genus Carica that hydrolyzes protein components of wounded tissue and stimulates cell proliferation.
Dependencies are inferred from the claim text.