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US 2003/0222007 A1Published application
Mass spectrometer autosampler
AssigneeBristol-Myers Squibb Company
InventorsMing Gu, Wenjeng Li, John W. Allen
Life of this patent
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Abstract
The present invention relates to an autosampler device useful in high pressure liquid chromatography (HPLC), and more particularly to a device useful for the automated introduction of small sample volumes into a HPLC system. Methods of analyzing low abundant protein samples using such a device are also included.
Claims43
An autosampler device for introducing a test sample into a HPLC system, comprising:
- a. a housing, said housing comprising at least two surfaces;
- b. one or more apertures defined by said housing, wherein said one or more apertures are each for receiving capillary tubing;
- c. a plate member within said housing, said plate member defining at least one opening for receiving a test sample container;
- d. a first movement member, wherein said first movement member is fixedly attached at a first side thereof to said housing and at a second side thereof to said plate member, and wherein said first movement member is for moving said plate member;
- e. a second movement member, wherein said second movement member is fixedly attached to said housing, and wherein said second movement member is for moving a vial positioned within said test sample container;
- and
- f. at least one inlet passageway in fluid communication with said housing, said inlet passageway being for introducing a fluid material into said housing.
4 more elements
A system for introducing a test sample into a HPLC system, comprising:
- a. a housing, said housing comprising at least two surfaces;
- b. one or more apertures defined by said housing, wherein said one or more apertures are each for receiving capillary tubing;
- c. a plate member within said housing, said plate member defining at least one opening for receiving a test sample container;
- d. a first movement member, wherein said first movement member is fixedly attached at a first side thereof to said housing and at a second side thereof to said plate member, and wherein said first movement member is for moving said plate member;
- e. a second movement member, wherein said second movement member is fixedly attached to said housing, and wherein said second movement member is for moving a vial positioned within said test sample container;
- f. at least one inlet passageway in fluid communication with said housing, said inlet passageway being for introducing a fluid material into said housing;
- g. a pressurizing system in fluid communication with said inlet passageway.
4 more elements
A HPLC system, comprising:
- a. a housing, said housing comprising at least two surfaces;
- b. one or more apertures defined by said housing, wherein said one or more apertures are each for receiving capillary tubing;
- c. a plate member within said housing, said plate member defining at least one opening for receiving a test sample container;
- d. a first movement member, wherein said first movement member is fixedly attached at a first side thereof to said housing and at a second side thereof to said plate member, and wherein said first movement member is for moving said plate member;
- e. a second movement member, wherein said second movement member is fixedly attached to said housing, and wherein said second movement member is for moving a vial positioned within said test sample container;
- f. at least one inlet passageway in fluid communication with said housing, said inlet passageway being for introducing a fluid material into said housing;
- g. a pressurizing system in fluid communication with said inlet passageway;
- and
- h. a mass spectrometer, said mass spectrometer being cooperative with said capillary tubing.
6 more elements
A method for analyzing a low abundant protein sample, comprising
- a. introducing a low abundant protein sample into an autosampler device, wherein said autosampler device comprises:
- i. a housing, said housing comprising at least two surfaces;
- ii. one or more apertures defined by said housing, wherein said one or more apertures are each for receiving capillary tubing;
- iii. a plate member within said housing, said plate member defining at least one opening for receiving a test sample container;
- iv. a first movement member, wherein said first movement member is fixedly attached at a first side thereof to said housing and at a second side thereof to said plate member, and wherein said first movement member is for moving said plate member;
- v. a second movement member, wherein said second movement member is fixedly attached to said housing, and wherein said second movement member is for moving a vial positioned within said test sample container;
- vi. at least one inlet passageway in fluid communication with said housing, said inlet passageway being for introducing a fluid material into said housing;
- vii. a pressurizing system in fluid communication with said inlet passageway;
- and
- viii. a mass spectrometer, said mass spectrometer being cooperative with said capillary tubing;
- b. acquiring data related to said low abundant protein sample.
8 more elements
Dependencies are inferred from the claim text.