Methods for tissue welding using laser-activated protein solders
AssigneeThe General Hospital Corporation
InventorsMichael R. Hamblin, John J. Khadem
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Abstract
Various tissue glues have drawback such as toxicity, causing inflammatory reactions or insufficient bonding strength. The present invention is directed to methods of form tissue adhesion by administering to tissues compositions comprising proteins conjugated to one or more novel photosensitizers and irradiating the composition. The composition may further comprise one or more proteins not conjugated to the photosensitizer. Additionally, the present invention relates to compositions and methods wherein increased ratios of protein to photosensitizer enhance weld strength.
Claims87
A method to weld tissue together, comprising the steps of:
- (a) applying to at least one tissue a composition comprising at least one photosensitizer and at least one proteinaceous compound or at least one lipid;
- and
- (b) irradiating said composition with electromagnetic energy;
- wherein said irradiating promotes adhesion of said tissue to at least a second tissue.
A method to weld tissue together, comprising the steps of:
- (a) applying to at least one tissue a composition comprising at least one photosensitizer;
- and
- (b) irradiating said composition with electromagnetic energy;
- wherein said photosensitizer is a cationic azine mon-azo dye, a tri-arylmethane dye, a chlorine, a tetrapyrrole, a cationic thiazine dye, or derivatives thereof;
- and wherein said irradiating promotes adhesion of said tissue to at least a second tissue.
A method to deliver a therapeutic agent to at least one living cell, comprising the steps of:
- (a) applying to at least one cell a composition comprising at least one at least one photosensitizer and at least a therapeutic agent;
- and
- (b) irradiating said composition with electromagnetic energy;
- wherein said irradiating promotes adhesion of said composition to said cell, and wherein said agent is thereby contacted with said cell.
A tissue glue/biomatrix composition, comprising at least one photosensitizer and at least one proteinaceous compound or at least one lipid.
A tissue glue/biomatrix composition, comprising at least one photosensitizer, wherein said photosensitizer is a cationic azine mon-azo dye, a tri-arylmethane dye, a chlorine, a tetrapyrrole, a cationic thiazine dye, or derivatives thereof.
Dependencies are inferred from the claim text.