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AssigneeUnigen Pharmaceuticals, Inc.
InventorQi Jia
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The present invention provides a novel composition of matter comprised of a mixture of two specific classes of compounds—Free-B-ring flavonoids and flavans—for use in the prevention and treatment of diseases and conditions mediated by the COX-2 and 5-LO pathways. The present invention further provides a novel method for simultaneously inhibiting the cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO) enzymes, and reducing cox-2 mRNA production. Finally, the present invention includes a method for weight loss and blood glucose control. The methods of this invention are comprised of administering to a host in need thereof an effective amount of the composition of this invention together with a pharmaceutically acceptable carrier. This invention relates generally to the prevention and treatment of diseases and conditions mediated by the cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO) pathways, including but not limited to the relief joint discomfort and pain associated with conditions such as osteoarthritis, rheumatoid arthritis, and other injuries that result from overuse.
A composition of matter comprised of a comprised of a mixture of at least one Free-B-ring flavonoid and at least one flavan.
A method for alleviating joint pain and stiffness and improving mobility and physical function comprising administering to a host in need thereof an effective amount of a composition comprised of a mixture of Free-B-ring flavonoids and flavans.
A method for and preventing and treating pathological conditions related to osteoarthritis and rheumatoid arthritis, said method comprising administering to a host in need thereof an effective amount of a composition comprising a mixture of Free-B-ring flavonoids and flavans together with a pharmaceutically acceptable carrier.
A method for inhibiting the enzymatic activity of the cyclooxygenase COX-2 enzyme said method comprising by administering to a host in need thereof an effective amount of a composition comprised of a mixture of Free-B-ring flavonoids and flavans.
The method of claim 20 wherein the composition is administered in a dosage selected from 0.01 to 200 mg/kg of body weight.
The method of claim 20 wherein the routes of the administration are selected from the group consisting of oral, topical, suppository, intravenous, and intradermic, intragaster, intramusclar, intraperitoneal and intravenous administration.
A method for inhibiting the enzymatic activity of the 5-lipoxygenase (5-LO) enzyme said method comprising by administering to a host in need thereof an effective amount of a composition comprised of a mixture of Free-B-ring flavonoids and flavans.
A method for simultaneously inhibiting the enzymatic activity of the COX-2 enzyme and the 5-LO enzyme said method comprising by administering to a host in need thereof an effective amount of a composition comprised of a mixture of Free-B-ring flavonoids and flavans.
A method for the inhibition of cox-2 mRNA production said method comprising administering to a host in need thereof an effective amount of a composition comprising a mixture of Free-B-ring flavonoids and flavans.
A method for preventing and treating diseases and conditions mediated by COX-2 and 5-LO pathways comprising administering to a host in need thereof an effective amount of a composition comprising a mixture of Free-B-ring flavonoids and flavans.
A method for reducing blood glucose concentrations said method comprising administering to a host in need thereof an effective amount of a composition comprising a mixture of Free-B-ring flavonoids and flavans.
A method for decreasing body mass index and causing weight loss said-method by administering to a host in need thereof an effective amount of a composition comprising a mixture of Free-B-ring flavonoids and flavans.
Dependencies are inferred from the claim text.