Agents and method for increaseing brain chaperonin levels

A method of modulating a level of a chaperone protein comprising administering to a patient a compound of the formula II;

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A method of modulating a level of ERP57 comprising administering to the patient a compound of the formula I

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• wherein R1, R2, and R3 are independently hydrogen, hydroxy, alkyl, hydroxyalkyl, cycloalkyl, alkoxy, cycloalkoxy, carboxyalkyl, acyl, acyloxyalkyl, —C(O)OH, —C(O)O—R4 (where R4 is an alkyl, cycloalkyl or aryl group), acyloxy, aryl, —OSO2R5 (where R5 is an alkyl, cycloalkyl or aryl group), halogen, or haloalkyl.

A method of modulating a level of ERP57 comprising administering to a patient a compound of the formula II;

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A method of alleviating a symptom of a disorder associated with decreased levels of chaperone proteins comprising administering to a patient a compound of the formula I;

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• wherein R1, R2, and R3 are independently hydrogen, hydroxy, alkyl, hydroxyalkyl, cycloalkyl, alkoxy, cycloalkoxy, carboxyalkyl, acyl, acyloxyalkyl, —C(O)OH, —C(O)O—R4 (where R4 is an alkyl, cycloalkyl or aryl group), acyloxy, aryl, —OSO2R5 (where R5 is an alkyl, cycloalkyl or aryl group), halogen, or haloalkyl.

A method of alleviating a symptom of Alzheimer's disease comprising administering to a patient a compound of the formula II;

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A pharmaceutical composition comprising a compound of formula

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• and a pharmaceutically acceptable carrier.

The use of a compound of formula I;

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• wherein R1, R2, and R3 are independently hydrogen, hydroxy, alkyl, hydroxyalkyl, cycloalkyl, alkoxy, cycloalkoxy, carboxyalkyl, acyl, acyloxyalkyl, —C(O)OH, —C(O)O—R4 (where R4 is an alkyl, cycloalkyl or aryl group), acyloxy, aryl, —OSO2R5 (where R5 is an alkyl, cycloalkyl or aryl group), halogen, or haloalkyl;
• in the manufacture of a medicament for the modulation of a level of a chaperone protein.

The use of a compound of formula I;

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• wherein R1, R2, and R3 are independently hydrogen, hydroxy, alkyl, hydroxyalkyl, cycloalkyl, alkoxy, cycloalkoxy, carboxyalkyl, acyl, acyloxyalkyl, —C(O)OH, —C(O)O—R4 (where R4 is an alkyl, cycloalkyl or aryl group), acyloxy, aryl, —OSO2R (where R5 is an alkyl, cycloalkyl or aryl group), halogen, or haloalkyl;
• in the manufacture of a medicament for the alleviation of a symptom of Alzheimer's disease.

The use of a compound of formula II;

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• in the manufacture of a medicament for the alleviation of a symptom of Alzheimer's disease.

The use of a compound of formula II;

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• in the manufacture of a medicament for the treatment of Alzheimer's disease.