3-amino-propoxphenyl derivatives (I)

A method for the treatment and/or prophylaxis of conditions for which potent, β1-specific beta blockers with a short duration of action in the systemic circulation would be particularly advantageous characterised in that it comprises administering to a patient in need of such treatment and/or prophylaxis an effective amount of a compound of formula (Ia)

• 11
• wherein
• R is 3′,4′-dimethoxyphenyl, R1 is hydrogen, and R2 is selected from methyl, ethyl, propyl, isobutyl and isopropyl;
• or
• R is 3′,4′-dimethoxyphenyl, R1 is selected from fluorine, chlorine and bromine, and R2 is selected from methyl, ethyl, propyl, isopropyl, isobutyl and cyclopropylmcthyl;
• or
• R is 4′-methoxyphenoxy, R1 is selected from hydrogen, fluorine, chlorine and bromine, and R2 is selected from methyl ethyl, propyl, isopropyl, isobutyl and cyclopropylmethyl;
• or
• R is 3′,4′-dimethoxyphenyl, R1 is cyano, and R2 is cyclopropylmethyl or isobutyl;
• or
• R is 4′-methoxyphenoxy, R1 is cyano, and R2 is isobutyl;
• and physiologically acceptable hydrolysable derivatives thereof having the hydroxy group in the 2-position of the 3-aminopropoxy side chain in esterified form,
• in their racemic and optically active forms, and their pharmaceutically acceptable acid addition salts.