Compositions and method for treating infection in cattle and swine
AssigneeSchering-Plough Animal Health Corporation
InventorsRaul E. Kohan, Kanwal J. Varma, Robert D. Simmons, Abu Huq
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Abstract
Novel formulations combining a non-steroidal anti-inflammatory drug (NSAID) such as flunixin, with a fluorinated chloramphenicol or thiamphenicol derivative antibiotic such as florfenicol are disclosed. Methods for using such formulations in the treatment and prevention of infectious diseases of bovines and swine, including bovine respiratory disease and swine respiratory disease, are also disclosed.
Claims29
A composition for the treatment of microbial infection in an animal comprising flunixin or one of its pharmaceutically acceptable salts and a compound of Formula I:
- 3
- wherein R is a member selected from the group consisting of methyl or ethyl or a halogenated derivative thereof, dihalogenodeuteriomethyl, 1-halogeno-1-deuterioethyl, 1,2-dihalogeno-1-deuterioethyl, azidomethyl and methylsulfonylmethyl;
- each of X and X′ is a member independently selected from the group consisting of NO2, SO2R1, SOR1, SR1, SONH2, SO2NH2, SONHR1, SO2NHR1, COR1, OR1, R1, CN, halogen, hydrogen, phenyl, and phenyl substituted by halogen, NO2, R1, PO2R1, CONHR1, NHR1, NR1R2, CONR1R2, OCOR1, or OR1, wherein each of R1. and R2 is a member independently selected from the group consisting of methyl, ethyl, n-propyl, isopropyl butyl, t-butyl, isobutyl and phenyl;
- and Z is hydrogen or an acyl group of a hydrocarboncarboxylic acid having up to 16 carbon atoms or an acyl group of an aminohydrocarboncarboxylic acid having up to 12 carbon atoms;
- and the pharmaceutically acceptable salts of said acyl groups.
A composition for the treatment of microbial infection in an animal comprising:
- a) florfenicol;
- b) flunixin or one of its pharmaceutically acceptable salts;
- and
- c) from about 5% to about 80% of an aprotic polar solvent.
Dependencies are inferred from the claim text.