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US 2003/0216441 A1Published application
Farnesyltransferase inhibitors
OwnerStephen L. Gwaltney II, Lissa T.J. Nelson +4inventors
InventorsStephen L. Gwaltney II, Lissa T.J. Nelson, Stephen J. O'Connor, Hing L. Sham, Gerard M. Sullivan, Weibo Wang
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Abstract
Compounds having the formula 1 are farnesyltransferase inhibitors. Also disclosed are methods of making the compounds, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds.
Claims16
A compound of formula (I)
- 10
- or a therapeutically acceptable salt thereof, wherein
- A is selected from the group consisting of aryl and heteroaryl;
- L is absent or selected from the group consisting of alkylene, N(R5), (CH2)nC(O), (CH2)nC(S), N(R5)(CH2)nC(O), CH(NR5R6)C(O), and (CH2)nSO2;
- wherein n is 0-4;
- and wherein each group is drawn with its left end attached to the carbon bearing R1 and R2 and its right end attached to the nitrogen;
- R1 and R2 are independently selected from the group consisting of hydrogen, alkenyl, alkyl, alkynyl, aryl, arylalkenyl, arylalkyl, arylalkynyl, halo, and hydroxy;
- wherein the aryl and the aryl part of the arylalkenyl and the arylalkynyl can be optionally substituted with one, two, three, four, or five substituents independently selected from the group consisting of alkoxy, alkoxyalkyl, alkoxycarbonyl, alkyl, alkylcarbonyl, cyano, halo, haloalkoxy, haloalkyl, hydroxy, and nitro;
- R3 and R4 are independently selected from the group consisting of hydrogen, alkoxy, alkoxycarbonyl, alkyl, aminocarbonyl, aryl, carboxy, cyano, halo, heteroaryl, heterocycle, and (heterocycle)carbonyl;
- and
- R5 and R6 are independently selected from the group consisting of hydrogen, alkyl, aryl, and arylalkyl:
8 more elements
Dependencies are inferred from the claim text.