Antitumoral ecteinascidin derivatives
AssigneePharmaMar, S.A.
InventorsMaria Flores, Andres Francesch, Gallego Pilar, Jose Luis Chicharro, Maria Zarzuelo, Carolina Fernandez, Ignacio Manzanares
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Abstract
Compounds having a fused ecteinascidin five ring system with a 1,4 bridge having the structure of formula (VIa or VIb) and compounds in which the —NH2 or —OH of the 1,4 bridge is derivatised are disclosed. Such compounds are useful in the treatment of tumours.
Claims10
A compound having a fused ecteinascidin five ring system with a 1,4 bridge having the structure of formula (VIa or VIb):
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- and compounds in which the —NH2 or —OH of the 1,4 bridge is derivatised;
- with the exception of ecteinascidin 583, ecteinascidin 597 or N-acetylecteinascidin 597, and with the exception of compounds 14 or 47 of U.S. Pat. No. 5,721,362.
A compound according to any preceding claim, wherein the —NH2 or —OH of the 1,4 bridge is derivatised.
A pharmaceutical composition comprising a compound having a fused ecteinascidin five ring system with a 1,4 bridge having the structure of formula (VIa or VIb):
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- and compounds in which the —NH2 or —OH of the 1,4 bridge is derivatised;
- with the exception of ecteinascidin 583 or 597, together with a pharmaceutically acceptable carrier.
The use of a compound having a fused ecteinascidin five ring system with a 1,4 bridge having the structure of formula (VIa or VIb):
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- and compounds in which the —NH2 or —OH of the 1,4 bridge is derivatised;
- with the exception of ecteinascidin 583 or 597, in the preparation of a medicament for use in the treatment of a tumour.
A method of treating a tumour which comprises administration of an effective amount of a compound having a fused ecteinascidin five ring system with a 1,4 bridge having the structure of formula (VIa or VIb):
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- and compounds in which the —NH2 or —OH of the 1,4 bridge is derivatised;
- with the exception of ecteinascidin 583 or 597.
Dependencies are inferred from the claim text.