Multicomponent complex for use with a substrate
AssigneeSurface Solutions Laboratories, Inc.
InventorMargaret P. Opolski
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Abstract
Compositions and methods for use with substrates which are useful in the sustained delivery of bioeffecting agents are described. The compositions of the invention include a multicomponent complex which attaches a bioeffecting agent to a substrate with an anchor provided by a linker compound which also forms a cleavable linkage so that the bioeffecting agent's release into the area surrounding the substrate occurs in a sustained manner over an extended period of time. The methods of the invention involve providing a bioeffecting composition on the surface of a substrate so that a bioeffecting agent may be released in a sustained manner over time.
Claims66
The combination of a multicomponent complex for delivering a bioeffecting agent for use with a substrate and an article, comprising a first complex for use with a substrate and for delivering a bioeffecting agent having the following formula:
- [Q]-[S]-[T]
- wherein Q is a bioeffecting domain component;
- S is a segment component containing at least two linking domains;
- and
- T is an anchoring moiety component,
- the components selected such that a cleavable linkage anchored to the substrate is formed which sustains the release of the bioeffecting agent over time, and a second article in contact with the first complex.
A multicomponent complex for delivering a bioeffecting agent for use with a substrate having the following formula:
- [Q]-[S]-[T]
- wherein Q is a bioeffecting domain component;
- S is a segment component containing at least two linking domains;
- and
- T is an anchoring moiety component,
- the components selected such that a cleavable linkage anchored to the substrate is formed which sustains the release of the bioeffecting agent over time.
A composition for delivering a bioeffecting agent for use with a substrate comprising:
- a first complex for use with a substrate and for delivering a bioeffecting agent having the following formula:
- [Q]-[S]-[T]
- wherein Q is a bioeffecting domain component;
- S is a segment component containing at least two linking domains;
- and
- T is an anchoring moiety component,
- the components selected such that a cleavable linkage anchored to the substrate is formed which sustains the release of the bioeffecting agent over time, and
- a second solution in contact with the first complex.
A packaged composition for delivering a bioeffecting agent for use with a substrate comprising:
- a container holding a compound supplying at least one component of a multicomponent complex having the following formula:
- [Q]-[S]-[T]
- wherein Q is a bioeffecting domain component;
- S is a segment component containing at least two linking domains;
- and
- T is an anchoring moiety component,
- the components selected such that a cleavable linkage anchored to the substrate is formed which sustains the release of the bioeffecting agent over time, and instructions for using the composition for delivering a bioeffecting agent.
A method for providing a sustained release bioeffecting coating on the surface of an article, the method comprising:
- applying a coating solution to a surface of the article such that a layer containing the sustained release bioeffecting coating is formed upon the article surface, wherein the formed layer contains a multicomponent complex containing a bioeffecting domain component, a segment component containing at least two linking domains, and an anchoring moiety component, the components selected such that a cleavable linkage anchored to the substrate is formed, and the release of the bioeffecting domain is sustained over time.
Dependencies are inferred from the claim text.