Micelles
AssigneeEisai Co., Ltd.
InventorsJames McShane, Tori Arens, Kazuhiro Kaneko, Tomohiro Watanabe, Kazuhide Ashizawa
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Abstract
The present invention provides micelles, solutions comprising micelles, methods for preparing micelles, and methods for delivering micelles to patients. The micelles have fixed, preselected hydrodynamic diameters and are formed from basic or acidic amphiphilic compounds.
Claims43
A method for preparing a micelle of Compound (1), a pharmaceutically acceptable salt thereof, and/or a stereoisomer thereof comprising:
- adding an amount of Compound (1) to a first aqueous alkaline solution comprising at least one basic metal salt, at least one neutral salt, and a predetermined concentration of metal ion;
- wherein Compound (1) is:
- 9
- thereby
- forming a second aqueous alkaline solution comprising micelles of Compound (1) having a preselected hydrodynamic diameter.
A micelle comprising Compound (1), a pharmaceutically acceptable salt thereof, and/or a stereoisomer thereof, wherein the micelle has a hydrodynamic diameter of about 5 nm to about 20 nm, wherein Compound (1) is:
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An aqueous solution comprising at least one micelle of Compound (1), a pharmaceutically acceptable salt thereof, and/or a stereoisomer thereof, wherein the micelle has a hydrodynamic diameter of about 5 nm to about 20 nm;
- and wherein Compound (1) is:
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A method for preparing micelles comprising:
- providing an amount of least one acidic amphiphilic compound, wherein the acidic amphiphilic compound comprises at least one ionizable group;
- adding the acidic amphiphilic compound to a first aqueous alkaline solution comprising at least one basic metal salt, at least one neutral metal salt, and a predetermined concentration of metal ion;
- thereby
- forming a second aqueous alkaline solution comprising micelles of the acidic amphiphilic compound with a preselected hydrodynamic diameter.
A method for preparing micelles comprising:
- providing an amount of least one basic amphiphilic compound that comprises at least one ionizable group;
- adding the basic amphiphilic compound to a first aqueous acidic solution comprising at least one protic acidic, at least one neutral metal salt, and a predetermined concentration of metal ion;
- thereby
- forming a second aqueous acidic solution comprising micelles of the acidic amphiphilic compound with a preselected hydrodynamic diameter.
Dependencies are inferred from the claim text.