Oligonucleotide modulation of her-1 expression
OwnerC Frank Bennett, Jacqueline R Wyatt +1inventors
InventorsC Frank Bennett, Jacqueline R Wyatt, Susan M Freier
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Abstract
Compounds, compositions and methods are provided for inhibiting the expressionof human Her-1. The compositions comprise oligonucleotides complementary to mRNA targeted to nucleic acids encoding Her-1. Methods of using these oligonucleotides for inhibition of Her-1 expression and for treatment of diseases such as cancers associated with overexpression of Her-1 are provided.
Claims19
A compound 8 to 50 nucleobases in length targeted to a nucleic acid molecule encoding epidermal growth factor receptor and comprising at least an 8 nucleobase portion of SEQ ID NO 27, 28, 29, 30, 31, 32, 33, 36, 37, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 51, 52, 53, 54, 55, 56, 57, 59, 60, 61, 62, 63, 64, 65, 66, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 99, 100, 101, 102, 103, 105, 106, 107, 108, 109, 110, 111, 112, 114, 116, 117, 118, 119, 120, 121, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 135, 136, 137, 138, 140, 141, 142, 143, 144, 145, 147, 148, 149, 150, 152, 154, 155, 156, 158, 159, 161, 162, 163, 164, 165, 166, 167, 168, 170, 171, 172, 173, 174, 175, 176, 177, 178, 179, 180, 181 or 182, wherein said oligonucleotide inhibits the expression of said human epidermal growth factor receptor.
A compound 8 to 50 nucleobases in length which specifically hybridizes with at least an 8-nucleobase portion of an active site on a nucleic acid molecule encoding epidermal growth factor receptor.
Dependencies are inferred from the claim text.