Chemically inert molecular tags
AssigneePharmacopeia, Inc.
InventorsJohn J. Baldwin, Roland E. Dolle III, Lawrence W. Dillard, Joan Guo
Life of this patent
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Abstract
A method for identifying a solid support in combinatorial synthesis or determining the structure of a compound in combinatorial synthesis. The method involves attaching, detaching and identifying at least one tag by detaching the tag from the solid support and reacting the detached tag with a fluoroalkanoyl acid or its alcohol-reactive equivalent. A preferred linker/tag is of formula 1 in which R1 is C13 to C33 alkane or ether.
Claims13
A method for identifying a solid support in combinatorial synthesis or determining the reaction history of a compound comprising attaching, detaching and identifying at least one alkane or oxaalkane tag, said identifying said tag being accomplished by reacting an alkanol or oxaalkanol obtained by detaching said tag from said solid support with a detection reagent chosen from fluoroalkanoyl acids and their alcohol-reactive equivalents.
A compound of formula
- 14
- wherein
- R1 is C13 to C33 alkane or oxaalkane;
- and
- R2 is chosen from —CHN2, —OH, halogen, —O-succinimide and —O-pentafluorophenyl.
Dependencies are inferred from the claim text.