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US 2003/0215867 A1Published application
System and method for characterizing microarray output data
AssigneeViaLogy Corp.
InventorSandeep Gulati
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AssigneeViaLogy Corp.
InventorSandeep Gulati
Estimating the term…
The current invention discloses a novel spectral transformation technique for characterizing digitized intensity output patterns from microarrays. This method yields improved sensitivity with reduced false positives and false negatives. Current microarray methods are overly sensitive to the detection of a visible distinction between pixels associated with probes and pixels associated with background. In one embodiment, a technique is disclosed that comprises the steps of: extracting pixels associated with an object of interest and transforming such pixels from an intensity representation to a spectral representation. In some embodiments, the extraction is based on a tessellated logarithmic spiral extraction that may yield a pixel core with a sampling of both foreground and background pixels. This core may then be computationally rescaled by 10X-10,000X to enhance spatial resolution. Once the extracted pixels are represented in the spectral regime, convolution with resolution-enhancement kernels may be used to accentuate morphological features capturing platform specific phenomenology.
A method for characterizing information from a pixellated output pattern of a microarray having one or more objects of interest, comprising the steps of:
30 The method of claim 23 wherein the convolution cascade is chosen from the group comprising:
A method for characterizing information from a pixellated output pattern of microarray representing one or more objects of interest, comprising the steps of:
A computer code product that characterizes information from a pixellated output pattern of microarray representing one or more objects of interest, comprising:
A computer system for characterizing information from a pixellated output pattern of a microarray representing one or more objects of interest, comprising:
A system for analyzing an output pattern of an array of detectors, each detector representing one or more objects of interest, comprising:
An article of manufacture, made by a method for characterizing information from a pixellated output pattern of an array of detectors, each detector representing one or more objects of interest, wherein the method comprises the steps of:
Dependencies are inferred from the claim text.