Variant cleavage stimulation factor and its encoding nucleic acid
AssigneeTexas Techn University
InventorsBrinda Dass, Clinton C. MacDonald, Allison Michelle Wallace-Shannon
Life of this patent
Estimating the term…
Abstract
The present invention relates to an isolated human nucleic acid molecule encoding a protein or polypeptide which controls RNA polyadenylation, an isolated mouse nucleic acid molecule encoding a protein or polypeptide which controls RNA polyadenylation, and nucleic acid constructs, host cells and an expression system incorporating the nucleic acid molecules. The present invention also discloses methods of diagnosing male infertility; a method of contraception for mammals; and a method for diagnosing a cancerous condition in a subject using the nucleic acid molecules and proteins of the present invention.
Claims45
An isolated human nucleic acid molecule encoding a protein or polypeptide which controls RNA polyadenylation, wherein the nucleic acid molecule is a variant of a somatic nucleic acid molecule and is functional when the somatic nucleic acid molecule is not functional.
An isolated mouse nucleic acid molecule encoding a protein or polypeptide which controls RNA polyadenylation, wherein the nucleic acid molecule is a variant of a somatic nucleic acid molecule and is functional when the somatic nucleic acid molecule is not functional.
Dependencies are inferred from the claim text.