Dispersible macromolecule compositions and methods for their preparation and use
AssigneeNektar Therapeutics
InventorsRobert M. Platz, Thomas K. Brewer, Terence D. Boardman
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Abstract
A process for preparing ultrafine powders of biological macromolecules comprises atomizing liquid solutions of the macromolecules, drying the droplets formed in the atomization step, and collecting the particles which result from drying. By properly controlling each of the atomization, drying, and collection steps, ultrafine dry powder compositions having characteristics particularly suitable for pulmonary delivery for therapeutic and other purposes may be prepared.
Claims30
A method for preparing dispersible dry powders of biological macromolecules, said method comprising:
- providing an evaporable liquid medium containing a predetermined concentration of the macromolecule and excipients;
- atomizing the liquid medium under conditions selected to form droplets having an average size below predetermined maximum;
- drying the droplets under conditions selected to form dispersible particles of the composite material containing the biological macromolecules, said particles having a moisture content below a predetermined moisture content, and
- collecting the particles with high yields.
A dispersible macromolecule composition for inhalation into the alveolar regions of the lung, said composition comprising particles having an average particle size below 5 μm and a rugosity measured by air permeametry above 2.
Dependencies are inferred from the claim text.