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US 2003/0215503 A1Published application
Palatable chewable tablet
AssigneePfizer Inc.
InventorsTanya Havlir, Kasra Kasraian
Life of this patent
Estimating the term…
Abstract
A palatable chewable tablet is described herein for oral administration of cetirizine dihydrochloride. The formulation is made more palatable by incorporating a combination of a grape flavoring agent with a vanilla flavoring agent.
Claims16
A palatable chewable tablet comprising
- (a) cetirizine or a pharmaceutically acceptable salt thereof,
- (b) a sweetener,
- (c) a combination of a grape flavoring and a vanilla flavoring in a ratio from about 4:1 to 2:1,
- (d) a cyclodextrin, and
- (e) one or more additional excipients.
2 more elements
A palatable chewable bi-layer tablet comprising
- (a) a first layer comprising
- (i) cetirizine or a pharmaceutically acceptable salt thereof,
- (ii) a combination of a grape flavoring and a vanilla flavoring in a ratio from about 4:1 to 2:1,
- (iii) beta-cyclodextrin,
- (iv) colorants, and
- (v) one or more additional excipients;
- and
- (b) a second layer comprising
- (i) mannitol or dextrinized sucrose,
- (ii) a combination of a grape flavoring and a vanilla flavoring in a ratio from about 4:1 to 2:1,
- (iii) colorants, and
- (iv) one or more additional excipients.
9 more elements
The tablet of claim 16 wherein the percent by tablet weight of each ingredient in said first layer is cetirizine dihydrochloride, 2.22%;
- betacyclodextrin, 18.33%;
- acesulfame K, 0.78%;
- colloidal silicon dioxide, 0.24%;
- microcrystalline cellulose, 9.75%;
- artificial grape flavor 486939, 0.13%;
- Pharma Sweet FL Pwd Nat(K), 0.04%;
- lactose monohydrate, 12.22%;
- Carmine Dye #09349, 0.05%;
- FD&C Blue Dye #2 Aluminum Lake, 0.05%;
- and magnesiuim stearate, 0.61%;
- and the percent by tablet weight of each ingredient in said second layer is mannitol, 53.60%;
- acesulfame K, 1.04%;
- artificial grape flavor 486939, 0.17%;
- Pharma Sweet FL Pwd Nat(K), 0.06%;
- Carmine Dye #09349, 0.07%;
- FD&C Blue Dye #2 Aluminum Lake, 0.07%;
- and magnesiuim stearate, 0.56%.
14 more elements
Dependencies are inferred from the claim text.