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US 2003/0215499 A1Published application
Use of completely linear short chain alpha-glucans as a pharmaceutical excipient
OwnerYong-Cheng Shi, Xiaoyuan Cui +1inventors
InventorsYong-Cheng Shi, Xiaoyuan Cui, Sibu Chakrabarti
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Abstract
This patent pertains to a tablet comprising as a binder a low amylose starch, which has been fully debranched using isoamylase and the method of making such tablet. Such binders are useful in any tabletting method, including direct compression, and can be used as a replacement for microcrystalline cellulose.
Claims25
A solid dosage form comprising a binder-filler and at least one active agent, said binder-filler consisting essentially of a starch composition comprising highly crystalline, fully debranched linear α-glucans, wherein the starch composition is characterized by
- a) a dextrose equivalent greater than about 4.0;
- b) a peak melting temperature, Tp as measured by DSC, of at least about 90;
- c) an enthalpy, ΔH as measured by DSC of at least about 25;
- d) an average particle size of at least about 25 microns and no more than about 90 microns.
1 more element
Dependencies are inferred from the claim text.