Therapeutic liposome composition and method of preparation
AssigneeSequus Pharmaceuticals, Inc.
InventorsTheresa M. Allen, Paul Steven Uster, Francis J. Martin, Samuel Zalipsky
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Abstract
Reagents for use in preparing a therapeutic liposome composition sensitized to a target cell are described. The reagents include a liposomal composition composed of pre-formed liposomes having an entrapped therapeutic agent and a plurality of targeting conjugates composed of a lipid, a hydrophilic polymer and a targeting ligand. The therapeutic, target-cell sensitized liposome composition is formed by incubating the liposomal composition with a selected conjugate.
Claims56
Reagents for use in preparing a therapeutic liposome composition sensitized to a target cell, said reagents comprising
- a liposomal composition composed of pre-formed liposomes having an entrapped therapeutic agent;
- and
- a plurality of conjugates, each conjugate composed of (i) a lipid having a polar head group and a hydrophobic tail, (ii) a hydrophilic polymer having a proximal end and a distal end, said polymer attached at its proximal end to the head group of the lipid, and (iii) a targeting ligand attached to the distal end of the polymer;
- wherein the therapeutic, target-cell sensitized liposome composition is formed by incubating the liposomal composition with a selected conjugate.
A plurality of targeting conjugates for use in preparing a targeted, therapeutic liposome composition, each conjugate composed of a (i) a lipid having a polar head group and a hydrophobic tail, (ii) a hydrophilic polymer having a proximal end and a distal end, said polymer attached at its proximal end to the head group of the lipid, and (iii) a targeting ligand attached to the distal end of the polymer.
A method of formulating a therapeutic liposome composition having sensitivity to a target cell, comprising
- selecting a liposomal composition composed of pre-formed liposomes having an entrapped therapeutic agent;
- selecting from a plurality of targeting conjugates a targeting conjugate composed of (i) a lipid having a polar head group and a hydrophobic tail, (ii) a hydrophilic polymer having a proximal end and a distal end, said polymer attached at its proximal end to the head group of the lipid, and (iii) a targeting ligand attached to the distal end of the polymer;
- and
- combining the selected liposome formulation and the selected targeting conjugate to form said therapeutic, target-cell sensitive liposome composition.
Dependencies are inferred from the claim text.