Methods and compositions for vaccination against or involving enterobacteriaceae bacteria
AssigneeBoard of Regents, The University of Texas System
InventorsGary R. Klimpel, David W. Niesel, Ashok Chopra, Jian Sha
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Abstract
The present invention concerns the use of methods and compositions to prophylactically or therapeutically vaccinate a subject against a pathogen or disease. Embodiments of the invention include the production of an attenuated bacterium from the family Enterobacteriaceae with a non-functional lipoprotein for use as a vaccine or as a vaccine vector for delivering antigens to a subject to be vaccinated. In certain embodiments, a bacterium of the Enterobacteriaceae family lacking a wild type LP, for example Salmonella typhimurium lacking a wild type LP, may be produced and used as a vaccine or vaccine vector.
Claims56
A bacterium of the family Enterobacteriaceae lacking a wild-type lipoprotein.
A bacterium of the family Enterobacteriaceae comprising an expression cassette encoding an antigen, wherein the bacterium is lipoprotein deficient.
A method for inducing an immune response comprising administering to a subject an effective amount of a vaccine composition comprising a lipoprotein deficient bacterium of the family Enterobacteriaceae, wherein the immune response is against the lipoprotein deficient bacteria or a heterologous antigen expressed by the lipoprotein deficient bacteria.
A method for producing a vaccine for a bacterial infection comprising generating a bacterium of the family Enterobacteriaceae lacking functional lipoprotein and formulating a pharmaceutically acceptable composition comprising the bacterium.
Dependencies are inferred from the claim text.