Methods for promoting cell transfection in vivo
OwnerAnthony Atala, Marcelle Machlufinventors
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Abstract
Methods, systems, and devices for promoting ultrasound-mediated gene transfection in vivo are disclosed. The methods and devices of the invention administer a gene formulation to the subject; and apply ultrasound energy to the subject, such that cell transfection is promoted. The ultrasound energy can be provided by an external source or an ultrasound source disposed inside the subject's body. For example, the source of ultrasound energy can be disposed on a catheter. The compositions suitable for ultrasound-mediated transfection can include genes (and plasmids containing such genes) in a pharmaceutically acceptable carrier and/or liposomes suitable for injection into a target site, aswell as implantable degradable matrix carriers.
Claims20
A method for promoting cell transfection in a subject, the method comprising:
- administering a gene formulation to the subject;
- and
- applying ultrasound energy to the subject, such that cell transfection is promoted in the subject;
- wherein the ultrasound energy is provided by an ultrasound source disposed inside the subject's body.
A system for promoting cell transfection in a subject, the apparatus comprising:
- means for administering a gene formulation to the subject;
- and
- an ultrasound applicator for applying ultrasound energy to the subject.
A catheter for promoting cell transfection in a subject, the catheter comprising:
- an elongate tubular assembly having at least one lumen and an opening at or near the distal end of the catheter;
- the distal end of the lumen being in fluid communication with the opening;
- and
- a source of ultrasound energy disposed at or near the distal end of the catheter.
Dependencies are inferred from the claim text.