Enzyme treatment of foodstuffs for celiac sprue
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsFelix Hausch, Gary Gray, Lu Shan, Chaitan Khosla
Life of this patent
Estimating the term…
Abstract
Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.
Claims24
A method of treating Celiac Sprue and/or dermatitis herpetiformis, the method comprising:
- administering to a patient an effective dose of a glutenase;
- wherein said glutenase attenuates gluten toxicity in said patient.
A formulation for use in treatment of Celiac Sprue and/or dermatitis herpetiformis, comprising:
- an effective dose of glutenase and a pharmaceutically acceptable excipient.
A method for treating a foodstuff to render said foodstuff less toxic to a Celiac Sprue patient, said method comprising contacting said foodstuff with a glutenase.
A purified oligopeptide selected from the group consisting of (SEQ ID NO:12) LQLQPFPQPQLPYPQPQLPYPQPQLPYPQPQPF, a deamidated counterpart oligonucleotide, an analog oligopeptide, and a conjugate of tissue transgluatonimase and a counterpart oligonucleotide.
Dependencies are inferred from the claim text.