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AssigneeBiosynexus Incorporated
InventorsJohn F. Kokai-Kun, Julie Adams, James J. Mond, Scott M. Walsh, Anjali G. Shah, Tatyana I. Chanturiya
Estimating the term…
Methods for treating patients in which damaged tissue or an indwelling prosthetic device or catheter has a bacterial biofilm growing thereon, to at least partially disrupt said biofilm, by administering at least one antibacterial enzyme that is lethal or damaging to the biofilm-forming bacteria in an amount that is effective to at least partially disrupt the biofilm upon contact therewith. Methods for prophylactically treating a patient, and methods for disinfecting or sterilizing a surface ex-vivo to remove a biofilm or prevent biofilm growth are also disclosed, as well as implantable articles susceptible to biofilm growth to which a prophylactic coating of an antibacterial enzyme has been applied.
A method for treating a patient in whom damaged tissue or an indwelling prosthetic device or catheter has a bacterial biofilm growing thereon, to at least partially disrupt said biofilm, comprising administering to said patient at least one antibacterial enzyme that is lethal or damaging to the biofilm-forming bacteria in an amount that is effective to at least partially disrupt the biofilm upon contact therewith.
A method for preventing biofilm growth on an implanted surface or damaged tissue in a patient susceptible thereto by administering a prophylactically effective amount of at least one antibacterial enzyme that is lethal or damaging to a biofilm-forming bacteria.
A method for disinfecting or sterilizing a surface ex-vivo to prevent biofilm-forming bacteria from growing thereon, comprising contacting said surface with a prophylactically effective amount of at least one antibacterial enzyme that is lethal or damaging to said biofilm-forming bacteria.
A prosthetic device or catheter, implantable in a patient in need thereof and having at least one surface susceptible to the growth of a bacterial biofilm, coated with at least one antibacterial enzyme that is lethal to a biofilm-forming bacteria in an amount effective to prevent biofilm formation.
A method for preparing a polymer composition resistant to the growth of a biofilm-forming bacteria on a surface formed therefrom comprising blending a polymer with an effective amount of at least one antibacterial enzyme that is lethal to a biofilm-forming bacteria.
A polymer composition for fabrication of a prosthetic device or catheter comprising a polymer suitable for use therein blended with at least one antibacterial enzyme that is lethal to a biofilm-forming bacteria in an amount that is effective to prevent biofilm formation on a surface formed from said polymer composition.
Dependencies are inferred from the claim text.