Latent reactive blood compatible agents
AssigneeSurModics, Inc.
InventorsPatrick E. Guire, Aron B. Anderson, Richard A. Amos, Terrence P. Everson
Life of this patent
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Abstract
A reagent and related method for use in passivating a biomaterial surface, the reagent including a latent reactive group and a bifunctional aliphatic acid (e.g., fatty acid), in combination with a spacer group linking the latent reactive group to the aliphatic acid in a manner that preserves the desired function of each group. Once bound to the surface, via the latent reactive group, the reagent presents the aliphatic acid to the physiological environment, in vivo, in a manner (e.g., concentration and orientation) sufficient to hold and orient albumin.
Claims44
A reagent for use in preparing a passivating biomaterial surface, the reagent comprising a latent reactive group and a bifunctional aliphatic acid, both groups being covalently attached to a spacer in a manner that permits the latent reactive group to be activated in order to attach the reagent to the surface, and that permits the aliphatic acid of the attached reagent to attract and bind a proteinaceous moiety in order to passivate the surface.
A reagent for use in preparing a passivating surface, the reagent selected from the group consisting of mono-2-(carboxymethyl) hexadecanamidopoly (ethylene glycol)200 mono-4-benzoylbenzyl ether, mono-3-carboxyheptadecanamidopoly (ethylene glycol)200 mono-4-benzoylbenzyl ether, mono-2-(carboxymethyl) hexadecanamidotetra (ethylene glycol) mono-4-benzoylbenzyl ether, mono-3-carboxyhepta-decanamidotetra (ethylene glycol) mono-4-benzoylbenzyl ether, N-[2-(4-benzoylbenzyloxy) ethyl]-2-(carboxymethyl) hexadecanamide, N-[2-(4-benzoylbenzyloxy)ethyl]-3-carboxyheptadecanamide, N-[12-(benzoylbenzyloxy) dodecyl]-2-(carboxymethyl) hexadecanamide, N-[12-(benzoylbenzyloxy) dodecyl]-3-carboxy-heptadecanamide, N-[3-(4-benzoylbenzamido) propyl]-2-(carboxymethyl) hexadecanamide, N-[3-(4-benzoylbenzamido) propyl]-3-carboxyheptadecanamide, N-(3-benzoylphenyl)-2-(carboxymethyl) hexadecanamide, N-(3-benzoylphenyl)-3-carboxyheptadecanamide, N-(4-benzoylphenyl)-2-(carboxymethyl) hexadecanamide, poly(ethylene glycol)200 mono-15-carboxypentadecyl mono-4-benzoylbenzyl ether, and mono-15-carboxypenta-decanamidopoly (ethylene glycol)200 mono-4-benzoylbenzyl ether.
A reagent for use in preparing a passivating surface, the reagent selected from the group consisting of:
- photoreactive endpoint copolymers of acrylamide and fatty acid monomers of the formula:
- 35
- photoreactive random copolymers of acrylamide and fatty acid monomers of the formula:
- 36
- photoreactive endpoint copolymers of N-vinylpyrrolidone and fatty acid monomers of the formula:
- 37
- photoreactive random copolymers of N-vinylpyrrolidone and fatty acid monomers of the formula:
- 38
- photoreactive siloxane copolymers containing fatty acid ligands of the formula:
- 39
- wherein the monomers shown in each polymer are present in random sequences and relative concentrations.
A method of preparing a passivating biomaterial surface, the method comprising the steps of:
- (a) providing a surface derivatized with a nucleophilic species, (b) reacting the surface with a reactive molecule under conditions suitable to react the reactive molecule with the nucleophilic species in order to form a bifunctional aliphatic acid attached to the surface by a covalent linkage.
Dependencies are inferred from the claim text.