Human milk produced by human mammary tissue implanted in non-human host animals and uses thereof
OwnerCharles Wilbur Slattery, Aladar Antal Szalayinventors
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Abstract
The invention discloses chimeric milk-producing tissues containing human mammary cells implanted into cleared mammary fat pad tissue or other suitable tissue of a non-human animal host, and discloses the use of human milk produced by chimeric milk-producing tissues. The invention further provides methods for avoiding problems of xenogeneic transplantation in chimeric milk-producing tissues.
Claims18
Chimeric milk-producing tissue comprising human donor cells comprising human mammary cells, multipotent human stem cells or other human cells that may be induced to differentiate into mammary tissue, wherein said human donor cells are placed into cleared mammary fat pads or other suitable sites in non-human host animals, wherein said cleared mammary fat pads or other suitable sites are capable of supporting development of human mammary tissue.
Method of generating chimeric milk-producing tissues comprising the steps of:
- a) obtaining human donor cells comprising human cells capable of differentiation into mammary tissue;
- b) placing said human donor cells into cleared mammary fat pads or other suitable sites in non-human host animals, wherein said cleared mammary fat pads or other suitable sites are capable of supporting development of human mammary tissue;
- c) measuring development of human mammary cells in chimeric tissue.
A non-human mammal having human-derived mammary cells inserted within cleared mammary fat pads of said mammal.
Dependencies are inferred from the claim text.