Fibroblast growth factor receptor activating gene l and related compositions and methods
AssigneeThe Government of the U.S.A. as represented by the Secretary of the Dept. of Health & Human Services
InventorsMatthew V. Lorenzi, Toru Miki
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Abstract
A novel gene designated as FRAG1 from and its encoded protein is disclosed. A fusion protein called FGFR2-ROS, which is formed by chromosomal rearrangement of rat FRAG1 with FGFR2 is also disclosed. Methods of producing FRAG1 protein, related fusion proteins, and antibodies against FRAG1 are disclosed, as are related pharmaceuticals and methods of using such nucleic acids, polypeptides, and antibodies are also disclosed.
Claims18
An isolated nucleic acid comprising at least 15 contiguous nucleotides of a fibroblast growth factor receptor activating gene 1 (FRAG1) nucleic acid that hybridizes under stringent conditions to the FRAG1 nucleic acid.
The isolated nucleic acid of claim 12, wherein the subject suffers from a neoplasm.
An isolated nucleic acid comprising at least 100 nucleotides having at least 70% nucleotide sequence similarity with a FRAG1 nucleic acid.
Dependencies are inferred from the claim text.