Use of derivatives of valproic acid and 2-valproenic acid amides for the treatment of mania in bipolar disorder
AssigneesYissum Research Development Company of the Hebrew University of Jerusalem, Teva Pharmaceutical Industries Ltd.
InventorsMitchell Shirvan, Meir Bialer
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Abstract
A method for the treatment of mania in bipolar disorder using derivatives of valproic acid and 2-valproenic acid amides having the following structures: 1 wherein R1, R2, and R3 are independently the same or different and are hydrogen, a C1-C6 alkyl group, an aralkyl group, or an aryl group, and n is an integer which is greater than or equal to 0 and less than or equal to 3, or a compound containing a valproic or a 2-valproenic moiety, as well as pharmaceutical compositions comprising these derivatives or compounds.
Claims17
A method of treating bipolar disorder in a subject comprising administering to the subject a therapeutically effective amount of a derivative of a valproic acid amide or a 2-valproenic acid amide having one of the following structures:
- 6
- wherein R1, R2, and R3 are independently the same or different and are hydrogen, a C1-C6 alkyl group, an aralkyl group, or an aryl group, and n is an integer which is greater than or equal to 0 and less than or equal to 3, to thereby treat the bipolar disorder.
Dependencies are inferred from the claim text.