Quinoline derivatives and medicinal use thereof

A quinoline derivative represented by the following formula (1) or a pharmacologically acceptable salt thereof:

• 100
• (wherein R1, R2, R3, R4, R5, R6 and R11 are each independently a hydrogen atom, a lower alkyl group of 1 to 4 carbon atoms, a halogen atom, a hydroxyl group, an alkyloxy group of 1 to 10 carbon atoms, a nitro group, an optionally substituted phenyl group, an amino group which may be substituted with a lower alkyl group of 1 to 4 carbon atoms, a cyano group, a carboxyl group, a lower alkyloxycarbonyl group of 1 to 4 carbon atoms, an aminocarbonyl group which may be substituted with a lower alkyl group of 1 to 4 carbon atoms, or a trifluoromethyl group;
• R7 and R8 are a hydrogen atom or a lower alkyl group of 1 to 4 carbon atoms and may directly bond to each other to form a carbon-to-carbon double bond;
• R9 is a hydroxyl group, an alkyloxy group of 1 to 10 carbon atoms, an optionally substituted phenyloxy group, a thiol group, an alkylthiol group of 1 to 10 carbon atoms, an optionally substituted phenylthiol group, a lower alkylcarbonyl group of 1 to 4 carbon atoms, an optionally substituted benzoyl group, a lower alkyloxycarbonyl group of 1 to 4 carbon atoms, an aminocarbonyl group which may be substituted with a lower alkyl group of 1 to 4 carbon atoms, or a carboxyl group;
• R10 is a hydroxyl group, a lower alkyl group of 1 to 4 carbon atoms, a lower alkyloxy group of 1 to 4 carbon atoms, an optionally substituted phenyloxy group or an amino group which may be substituted with a lower alkyl group of 1 to 4 carbon atoms;
• and n is an integer of 1 to 4).