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OwnerNeil Ruderman, Edward W Kraegen +1inventors
InventorsNeil Ruderman, Edward W Kraegen, Yasuo Ido
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The long-term usage of AICR (5-aminio, 4-imidazole carboxamide riboside) to produce sustained metabolic and biological changes in mammals that overcome insulin resistance, i.e., increase insulin sensitivity, and result in benefits in diseases and conditions such as diabetes, hypertension, atherosclerosis, polycystic ovary syndrome and gallstones is described long-term usage of AICAR, particularly intermittent administration, e.g., three days per week, appears to have some of the positive effects of exercise, having an impact on the amount Of food consumed by a subject and resulting in reduced fat build-up and increase in muscle mass. Therefore, AICAR administration has a positive impact in reducing obesity. AICAR can also Prove useful in preventing or treating vascular diseases associated with hyperglycemia, high plasma levels of free fatty acids (FFA) and triglyceride, and insulin resistance by virtue of the fact that this agent activates fatty acid oxidation. Animal tests have Shown that chronic intermittent treatment with AICAR has not resulted in any noticeable toxic effects. AICAR and related compounds are activators of AMP-activated protein kinase (AMPK) and, furthermore, are effective at decreasing malonyl CoA levels in the animal.
A method for prophylaxis or treatment of a disease or condition associated with hyperglycemia, insulin resistance, insulin resistance syndrome or obesity, said method comprising the steps of:
The method of claim 143, wherein said disease or condition is atherosclerotic vascular disease.
A method of identifying an agent for prophylaxis or treatment of a disease or condition associated with hyperglycemia, insulin resistance, insulin resistance syndrome or obesity, said method comprising the steps of:
A method of identifying an agent for prophylaxis or treatment of a disease or condition associated with hyperglycemia, insulin resistance, insulin resistance syndrome or obesity, said method comprising the steps of:
Dependencies are inferred from the claim text.