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OwnerCameron Skinner, Thompson Tang +6inventors
InventorsCameron Skinner, Thompson Tang, D. Jed Harrison, Nicolas Bings, Can Wang, Gregor Ocvirk, Jianjun Li, Pierre Thibault
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A method is provided for joining a microchip device to a capillary tube. The microchip device has a capillary channel opening onto an edge surface of the device. A short hole is drilled into the edge surface, aligned with the capillary channel. The drilling is done with a flat bottom, preferably by a two-step drilling process. Then, the end of the capillary can be inserted into the hole so that its end is substantially flush with the flat bottom of the hole, thereby eliminating dead volume. Testing has shown that this connection provides very little band broadening of samples transported through the capillary channel into the capillary tube. The tip of the capillary tube can be tapered, so that it is suitable for use as an electrospray source for a mass spectrometer.
An article of manufacture prepared by a process comprising:
A method of joining a capillary tube to a microchip including at least one capillary channel that opens onto an edge surface of the microchip, the method comprising:
A method of joining a capillary tube to a microchip including at least one capillary channel that opens onto an edge surface of the microchip the method comprising:
Dependencies are inferred from the claim text.