Compositions and methods for therapeutic use
AssigneeCanji, Inc.
InventorsHeidrun Engler, Bernard G. Huyghe, Daniel C. Maneval, Paul Shabram
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Abstract
A method and pharmaceutical composition for the treatment of cancer using a gene delivery system, such as a viral vector delivery system, comprising a therapeutic gene such as p53 or a retinoblastoma tumor suppressor gene wherein the gene delivery system is formulated in a buffer comprising a delivery-enhancing agent such as ethanol or a detergent.
Claims39
A method of administering a therapeutic agent to a tissue having an epithelial membrane, comprising administering a therapeutically effective amount of the therapeutic agent formulated in a buffer comprising a detergent.
A pharmaceutical composition comprising a therapeutically effective amount of a therapeutic agent formulated in a buffer comprising a detergent.
A method of treating bladder cancer comprising administration of a therapeutically effective amount of a therapeutic gene contained within a gene delivery system that is formulated in a buffer comprising a delivery-enhancing agent.
A pharmaceutical formulation for administration of a recombinant adenovirus, comprising about 109-1011 PN/ml recombinant adenovirus, about 2-10 mM Big CHAP or about 0.1-1.0 mM TRITON®-X-100 detergent, phosphate buffered saline (PBS), about 2-3% sucrose (w/v) and about 1-3 mM MgCl2, about pH 6.4-8.4.
Dependencies are inferred from the claim text.