Human oxalyl-CoA decarboxylase
AssigneeHuman Genome Sciences, Inc.
InventorsHenrik S. Olsen, Timothy A. Coleman, Mark D. Adams
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Abstract
A human oxalyl-COA decarboxylase polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques and for producing an antibody against such polypeptide are disclosed. Also disclosed is a combination of the polypeptide of the present invention and a suitable pharmaceutical carrier for providing a therapeutically effective amount of the polypeptide for the treatment of urolithiasis and hyperoxaluria. Also disclosed are assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention.
Claims18
An isolated polynucleotide comprising a member selected from the group consisting of:
- (a) a polynucleotide encoding the polypeptide comprising amino acid 1 to amino acid 578 as set forth in SEQ ID NO:2;
- (b) a polynucleotide capable of hybridizing to and which is at least 70% identical to the polynucleotide of (a);
- and
- (c) a polynucleotide fragment of the polynucleotide of (a) or (b).
An isolated polynucleotide comprising a member selected from the group consisting of:
- (a) a polynucleotide which encodes a mature polypeptide having the amino acid sequence expressed by the DNA contained in ATCC Deposit No. ______;
- (b) a polynucleotide which encodes a polypeptide having the amino acid sequence expressed by the DNA contained in ATCC Deposit No. ______;
- (c) a polynucleotide capable of hybridizing to and which is at least 70% identical to the polynucleotide of (a);
- and
- (d) a polynucleotide fragment of the polynucleotide of (a), (b) or (c).
A polypeptide selected from the group consisting of (i) a polypeptide having the deduced amino acid sequence of SEQ ID NO:2 and fragments, analogs and derivatives thereof;
- and (ii) a polypeptide encoded by the cDNA of ATCC Deposit No. 75715 and fragments, analogs and derivatives of said polypeptide.
Dependencies are inferred from the claim text.