Growth differentiation factor-14
AssigneeThe Johns Hopkins University School of Medicine
InventorsSe-Jin Lee, Christopher Rankin
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Abstract
Growth differentiation factor-14 (GDF-14) is disclosed along with its polynucleotide sequence and amino acid sequence. Also disclosed are diagnostic and therapeutic methods of using the GDF-14 polypeptide and polynucleotide sequences.
Claims48
A method of detecting the presence of GDF-14 protein in a sample comprising contacting an antibody that binds to GDF-14 with the sample and detecting binding of the antibody, wherein binding of the antibody to the GDF-14 protein indicates the presence of the GDF-14 protein in the sample.
A method of determining the amount of GDF-14 protein in a sample, comprising contacting an antibody that binds GDF-14 protein with the sample and detecting the amount of the antibody bound to the GDF-14 protein in the sample, wherein the amount quantifies GDF-14 protein in the sample.
Substantially pure growth differentiation factor-14 (GDF-14).
The antibodies of claim 27, wherein the antibodies are polyclonal.
A method of treating a cell proliferative disorder or immunologic disorder associated with expression of GDF-14, comprising contacting the cells with a reagent which suppresses the GDF-14 activity.
Dependencies are inferred from the claim text.