Treatment of insulin resistance
AssigneeThe Regents of the University of California
InventorsJerrold M. Olefsky, Tahir S. Pillay
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Abstract
Methods and compositions are provided for the treatment of insulin-resistance through the inhibition of protein kinase C-mediated phosphorylation of the amino acid residue Ser1270 of the insulin receptor. Methods for testing candidate compounds suitable for inhibition of serine-phosphorylation by protein kinase C are also provided.
Claims41
A protein kinase C antagonist characterized by activity in inhibition of protein kinase C-mediated phosphorylation of serine residue 1270 of an insulin receptor.
A purified polynucleotide encoding a polypeptide having the amino acid sequence DDLHPSFPEVS (SEQ ID NO:
- 1), with the proviso that polynucleotide does not encode a native insulin receptor.
A method of testing a candidate compound for protein kinase C antagonist activity comprising:
- contacting the candidate compound with protein kinase C and a substrate for protein kinase C, and detecting a level of phosphorylation of the substrate, wherein the substrate has an insulin receptor amino acid sequence, the amino acid sequence comprising serine residue 1270 of the insulin receptor.
A purified polynucleotide encoding a serine phosphorylation-resistant human insulin receptor.
Dependencies are inferred from the claim text.