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US 2003/0211537 A1Published application
Opioid receptors: compositions and methods
AssigneeArch Development Corporation
InventorsGraeme I. Bell, Terry Reisine, Kazuki Yasuda
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AssigneeArch Development Corporation
InventorsGraeme I. Bell, Terry Reisine, Kazuki Yasuda
Estimating the term…
The invention relates generally to compositions of and methods for obtaining opioid receptor polypeptides. The invention relates as well to polynucleotides encoding opioid receptor polypeptides, the recombinant vectors carrying those sequences, the recombinant host cells including either the sequences or vectors, and recombinant opioid receptor polypeptides. By way of example, the invention discloses the cloning and functional expression of at least three different opioid receptor polypeptides. The invention includes as well, methods for using the isolated, recombinant receptor polypeptides in assays designed to select and improve substances capable of interacting with opioid receptor polypeptides for use in diagnostic, drug design and therapeutic applications.
An isolated and purified polynucleotide that encodes an opioid receptor polypeptide.
An isolated and purified opioid receptor polypeptide.
An antibody immunoreactive with an opioid receptor polypeptide.
A process of detecting a messenger RNA transcript that encodes an opioid receptor polypeptide, wherein the process comprises:
A diagnostic assay kit for detecting the presence of an opioid receptor polypeptide in a biological sample, said kit comprising a first container containing a first antibody capable of immunoreacting with said opioid receptor polypeptide, wherein said first antibody is present in an amount sufficient to perform at least one assay.
A diagnostic assay kit for detecting the presence, in a biological sample, of an antibody immunoreactive with an opioid receptor polypeptide, said kit comprising a first container containing an opioid receptor polypeptide that immunoreacts with said antibody, and wherein said polypeptide is present in an amount sufficient to perform at least one assay.
A process of screening a substance for its ability to interact with an opioid receptor, said process comprising the steps of:
A process of making a product with an ability to act as a specific agonist of a kappa opioid receptor, said process comprising the steps of:
Dependencies are inferred from the claim text.